继发性不孕症与免疫性抗体及性激素水平相关性研究

Correlation between secondary infertility and autoimmune antibodies,hormones

目的探讨继发性不孕症患者免疫性抗体与激素水平的关系。方法选取106例继发性不孕症患者测定其免疫性抗体及激素水平,与75例健康对照者免疫抗体及激素水平对比。结果对照组与继发性不孕患者组免疫抗体比较,As Ab、Ao Ab、Em Ab、HCGAb 4种抗体在继发性不孕组的检出率明显高于对照组,差异均有统计学意义(P<0.01)。继发性不孕症患者中抗体全为阴性者有38例,其激素水平与抗体阳性者对比发现,除了E2在抗体阴性组的水平高于抗体阳性组外,其他5种激素FSH、LH、T、PRL、INS水平在抗体阳性组的水平均高于抗体阴性组,而E2水平明显降低,差异均有统计学意义(P<0.05)。结论免疫抗体及激素是导致继发性不孕症的重要原因,抗体可以导致不孕,激素紊乱也会导致不孕。

Objective To discuss the correlation between autoimmune antibodies and hormones in secondary infertility patients.Methods Autoimmune antibodies and hormones of 106 secondary infertility patients were measured and compared with that of75 healthy volunteers. Results Compared the immune antibody with the control group in patients with secondary infertility group,the detection rates of As Ab,Ao Ab,Em Ab,HCGAb in the secondary infertility group was significantly higher than that in the control group,and the difference was statistically significant（ P〈0. 01）. There were 38 cases with all antibody negative in secondary infertility patients,comparing their hormone levels with antibody-positive group,in addition that the level of E2 in antibody negative group was higher than that of antibody positive group,the other 5 hormones,FSH,LH,T,PRL,INS levels in the antibody positive group were higher than those in the antibody negative group,while,E2 level decreased significantly,with the differences statistically significant（ P〈0. 05）. Conclusion Immune antibodies and hormones are important causes of secondary infertility,antibodies can lead to infertility,so can hormonal disorders.