舟山海岛地区孕妇甲状腺激素水平对妊娠结局的影响

Effect of thyroid hormone on the pregnancy outcome among pregnant women in Zhoushan islands area

目的了解舟山地区妊娠妇女的孕期甲状腺激素对妊娠结局的影响。方法选取2012年3月-2013年1月怀孕开始的妇女428名,检测血清甲状腺激素水平,调查其妊娠结局。结果 31岁~44岁年龄组TT4水平低于其他年龄组,差异有统计学意义（P〈0.05）。31岁~44岁年龄组甲状腺激素异常率（19.51%）高于18岁~23岁年龄组（6.56%）和24岁~30岁年龄组（8.28%）,差异均有统计学意义（χ^2值分别为3.96、4.91,P〈0.05）。24岁~30岁年龄组中,甲状腺激素异常孕妇的不良妊娠结局发生率（32.14%）高于甲状腺激素正常孕妇（7.69%）,差异有统计学意义（χ^2=17.33,P〈0.01）。31岁~44岁年龄组中,甲状腺激素异常孕妇的不良妊娠结局发生率（37.50%）高于甲状腺激素正常孕妇（6.06%）,差异有统计学意义（χ^2=5.94,P〈0.05）。结论加强对海岛地区高龄孕妇甲状腺激素的监控,有助于减少防范其不良妊娠结局。

Objective To learn the effect of thyroid hormone in pregnancy on the pregnancy outcome among pregnant women in Zhoushan area. Methods 428 pregnant women during March 2012-January 2013 were selected,and their serum levels of thyroid hormone were detected. The pregnancy outcomes were investigated. Results TT4 levels in 31-44 age group were significantly lower than the other age groups,with the difference statistically significant（ P〈0. 05）. The abnormal rate（ 19. 51%）of thyroid hormone in 31-44 age group was significantly higher than that of the 18-23 age group（ 6. 56%） and the 24-30 age group（ 8. 28%）,with the differences statistically significant（ χ^2= 3. 96,4. 91,P〈0. 05）. In 24-30 age group,the occurrence rate of abnormal pregnancy outcome rate in women with abnormal serum thyroid level（ 32. 14%） was significantly higher than that in women with normal serum thyroid level（ 7. 69%）,with the difference statistically significant（ χ^2= 17. 33,P〈0. 01）. In 31-44 age group,that of abnormal pregnancy outcome rate in women with abnormal serum thyroid level（ 37. 50%）was significantly higher than that in women with normal serum thyroid level（ 6. 06%）,with the difference statistically significant（ χ^2= 5. 94,P〈0. 05）. Conclusion To strengthen the monitoring of thyroid hormone in elderly pregnant women in islands area is helpful for the prevention of abnormal pregnancy outcome.