临床常见检测指标在糖尿病慢性肾脏疾病中的应用价值分析

Application of common clinical indicators in diabetic chronic kidney disease

目的分析临床常见检测指标在糖尿病慢性肾脏疾病(CKD)诊断中应用的价值。方法选取T2DM患者78例,根据UAER结果将患者分为单纯T2DM组、早期CKD组(20μg/min≤UAER<200/μg/min)和临床期CKD组(UAER≥200μg/min),比较各组临床指标。结果 Logisitc回归分析显示,转铁蛋白(TF)、TC、Scr、SUA、BMI、SBP为CKD发生的危险因素;受试者工作特征(ROC)曲线分析显示,TF和TC联合诊断有较大的诊断价值(AUC=0.959);判别分析得到TF、TC、SBP、GFR为筛选后指标在早期CKD组和临床期CKD组分类正确率为87.2%。结论 TF、TC、Scr、SUA、BMI、SBP为CKD的危险因素,综合简便性及诊断价值,TF与TC联合诊断价值较高;以此常见指标建立的判别函数对CKD的诊断有一定的参考价值。

Objective To investigate the diagnostic value of common clinical indicators in diabetic chronic kidney disease. Methods A total of 78 patients with T2DM were enrolled in this study ,and divided into three groups ：simple T2DM group ,early‐stage of CKD group （20 μg/min≤ UAER〈 200 μg/min） and clinical stage of CKD group （UAER≥200 μg/min）. Clinical indicators were compared among the three groups. Results Logistic regression analysis demonstrated that TF ,TC ,Scr ,SUA ,BMI ,SBP were independent risk factors for CKD. ROC curve analysis showed that TF combined with TC showed good value in diagnosing diabetic CKD （AUC=0.959）. Discriminant analysis based on TF ,TC ,SBP ,GFR has an accuracy rate of 87.2% in differentiating early‐stage and clinical stage of CKD. Conclusion TC ,Scr , SBP are risk factors for CKD. TF＋ TC shows good value and convenience in diagnosing diabetic CKD.The discriminant analysis based on these indicators has a certain reference value in CKD diagnosis.