飞行人员广泛性焦虑障碍与5-羟色胺2A受体基因多态性相关性的研究

Research on Correlation Between Generalized Anxiety Disorder and Polymorphism of 5-HT2A Gene in Pilots

目的探讨飞行人员广泛性焦虑障碍(generalized anxiety disorder,GAD)与5-羟色2A(5-HT2A)受体基因T102C和A-1438G位点多态性的关系。方法用聚合酶链反应技术(PCR)检测19例飞行人员GAD患者及55名正常健康对照飞行人员两基因位点的多态性。结果 GAD组与健康对照组飞行人员在T102C位点基因型的构成比上不存在统计学差异(P>0.05),在A-1438G位点基因型的构成比上存在统计学差异(P<0.05),患者组G-1438等位基因型频率(65.8%)明显高于对照组(34.2%)。结论5-HT2A基因A-1438G位点多态性可能与飞行人员GAD相关,G-1438等位基因可能是飞行人员GAD的一个易感基因。

Objective To study the correlation between T102 C and A-1438 G polymorphism of 5-Hydroxytryptamine 2A receptor（ 5-HT2A） gene with generalized anxiety disorder（ GAD） in pilots. Methods5-HT2 A gene genotype was assayed with polymerase chain reaction（ PCR） in 19 GAD pilots and 55 health control pilots. Results There was no significant difference between GAD pilots and controls in T102C（ P〉0. 05）. There were significant differences between GAD pilots and controls in constituent ratio of A-1438G（ P〈0. 05）. The frequency of G-1438 allele in GAD pilots（ 65. 8%） was significantly higher than that in controls（ 34. 2%）. Conclusion The polymorphisms of A-1438 G in 5-HT2 A gene may be correlated with GAD in pilots; G-1438 allele may be a susceptible gene for pilots with GAD.