乙酰化调控在HBV慢性化感染过程中的作用及其作为抗病毒治疗靶位的潜在应用进展

Roles of acetylation-dependent regulation in pathogenesis of chronic hepatitis B virus infection:Potential application as targets for antiviral treatment

近年来,许多研究证实,表观遗传学及乙酰化调控在慢性肝炎、原发性肝癌的发病机制中都发挥了重要作用.本文较系统地介绍了乙酰化调控及相关信号通路在乙型肝炎病毒(hepatitis virus B,HBV)慢性化感染过程中的作用及可能机制,为HBV慢性化感染提供了新的潜在干预治疗思路.

Inrecent years,many studies have confirmed that epigenetics and acetylationdependent regulation play important roles in the pathogenesis of chronic hepatitis and primary hepato cellular carcinoma.This paper systematically introduces the roles and possible mechanisms of acetylation and its related signal pathways in the pathogenesis of chronic hepatitis B virus（HBV） infection, which may provide a potential novel strategy for the therapy of chronic HBV infection.