生长抑素受体2在结直肠神经内分泌肿瘤中的表达及意义

Expression of somatostatin receptor subtype 2 in colorectal neuroendocrine neoplasms

目的:研究生长抑素受体(somatostafin receptor,SSTR)亚型SSTR2在结直肠神经内分泌肿瘤组织中的表达情况,以及与临床病理特征的关系.方法:收集结直肠神经内分泌瘤患者组织标本及相关临床病理资料,应用免疫组织化学En Vision二步法检测肿瘤组织中SSTR2表达情况.结果:56例患者纳入研究,其中SSTR2阳性表达率为76.8%.SSTR2的阳性表达与淋巴结转移、肿瘤浸润肌层、出现远处转移关系密切(P<0.05),但是与性别和年龄无关(P>0.05).此外,肿瘤的最大径及组织学分级也与SSTR2阳性表达有关(P<0.05).结论:SSTR2异常表达与重要的临床病理学特征相关,SSTR2可能成为一个新的结直肠神经内分泌瘤诊断和预后的分子指标.

AIM： To detect the expression of somatostafi n receptor subtype 2（SSTR2） in human colorectal neuroendocrine neoplasms and analyze its clinicopathological signifi cance. METHODS： Clinical samples and clinicopathological information of patients with colorectal neuroendocrine neoplasms were collected.The expression of SSTR2 in tumor tissues was examined by immunohistochemical En Vision method.RESULTS： A total of 56 patients were enrolled in this study. The rate of positive expression of SSTR2 in colorectal neuroendocrine neoplasms was 76.8%. Positive expression of SSTR2 in tumor tissues was associated with lymph node metastasis, muscularis invasion and distant metastasis（P 0.05）, but not with sex or age（P 0.05）. In addition, a signifi cant correlation was found between SSTR2 expression and tumor diameter and histological grade（P 0.05）. CONCLUSION： Abnormal expression of SSTR2 correlates closely with some important clinicopathological characteristics of colorectal neuroendocrine neoplasms. SSTR2 may be used as a new biomarker for the diagnosis and prognosis evaluation of colorectal neuroendocrine neoplasms.