摘要
晚期胃癌生存期短,预后差,目前的指南均推荐姑息性治疗为主.而鉴于转化治疗在结直肠癌肝转移治疗上的成功,其对于晚期胃癌也有着相似的启示.一些小样本的研究发现转化治疗能给晚期胃癌患者带来较姑息治疗显著的生存期提高,而由于目前转治化疗在晚期胃癌的应用上尚缺乏有效的循证医学证据,多学科协作组(multidisciplinary team,MDT)模式是当前的晚期胃癌转化治疗的重要保障.晚期胃癌的转化往往需要多个学科配合的综合治疗,本文更多的从非外科角度上对转化治疗在病例、治疗方案和治疗时机的选择进行全面论述,旨在为临床治疗提供参考.
Patients with advanced gastric cancer（AGC） have short overall survival and poor prognosis. Current guidelines recommend palliative treatments. The success of conversion therapy in liver metastases of colorectal cancer gives an inspiration to AGC treatment. Some small sample studies indicated that conversion therapy provided AGC patients longer overall survival time compared to those who received palliative treatments. The application of conversion therapy in AGC is still lack of effective evidence of evidence-based medicine. The multidisciplinary team（MDT） mode is an important guarantee for the conversion therapy of AGC. The conversion therapy of AGC requires multi-disciplinary comprehensive treatment. This article makes a comprehensive discussion on the choice of cases, treatment plans and timing of treatment from the perspective of nonsurgical treatment, with an aim to provide a reference for clinical treatments.
出处
《世界华人消化杂志》
CAS
2016年第18期2830-2837,共8页
World Chinese Journal of Digestology
基金
上海市中医药事业发展三年行动计划基金资助项目
No.ZY3-CCCX-3-2003~~
关键词
胃癌
转化治疗
多学科综合治疗
Gastric cancer
Conversion therapy
Multidisciplinary treatment
