炎症性肠病患者服药依从性影响因素的研究进展

Factors affecting adherence to treatment in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种慢性炎症性胃肠道疾病,包括溃疡性结肠炎(ulcerative colitis,UC)与克罗恩病(Crohn's disease,CD),属于一种难治性疾病.氨基水杨酸制剂、激素、免疫抑制剂和生物制剂仍然是现阶段治疗的基础,绝大多数患者需要这些药物诱导缓解并长期用药维持缓解,这就使得患者治疗方案的选择和服药依从性同等重要,依从性的高低影响着疾病预后的好坏,目前治疗方案已经得到巨大的优化,但服药依从性较少引起人们的关注.本文综述国内外关于IBD患者服药依从性的影响因素的相关研究进展,帮助医务人员识别影响依从性的因素以期更有效地管理患者.

Infl ammatory bowel disease（IBD） is a group of chronic inflammatory diseases of the intestine,which includes Crohn＇s disease（CD） and ulcerative colitis（UC）. IBD is a kind of refractory disease. Currently,drugs including 5-ASA,corticosteroids,and immunosuppressant drugs as well as biological agents are the basic treatment. The vast majority of patients need these drugs to induce and maintain remission. The choice of treatment and patients＇ adherence are equally important,because the disease prognosis is related to the medication adherence.Although current treatments have been greatly optimized,little attention has been paid to many factors associated with non-adherence to IBD medications in China. This article reviews the domestic and foreign research on the factors influencing IBD medication adherence,with an aim to help medical personnel identify factors that infl uence treatment adherence and effectively manage this refractory disease.