谈谈质子泵抑制剂与促动力药联合用药问题

Combined use of proton pump inhibitors and prokinetics: Feasibility and cautions

质子泵抑制剂(proton pump inhibitor,PPI)是治疗酸相关性疾病的首选药物.促动力药在胃食管反流和胃肠动力不足所致的疾病中应用广泛.但国内部分作者在讨论PPI与促动力药临床合理用药问题时认为两类药物不可同时服用,使得临床医生用药和临床药师进行处方合理用药评价时产生误解,无所适从.本文就PPI和促动力药能否合用,以及联合应用时应注意的问题进行讨论,供临床医生和药师参考.

Proton pump inhibitors（PPIs） are a group of preferred medicines for treating acid related diseases. Prokinetic drugs are widely used in gastroesophageal reflux disease and diseases caused by gastrointestinal motility.The combined use of PPIs and prokinetic drugs has been considered irrational when some authors discuss the clinical rational use of PPIs and prokinetic drugs,and they recommended that PPI and prokinetic drugs should not be taken at the same time,but should be separated by 1-2 h. This is some what misleading for clinicians to prescribe medicines and pharmacists to evaluate the rational use of the drugs. In this paper,we discuss the feasibility and cautions of combined use of PPIs and prokinetic drugs,to provide a reference for clinicians and pharmacists.