曲札茋苷原料中铅、镉、铜、砷、汞残留量的测定

Determination of Residual Pb,Cd,Cu,As and Hg in Piceatannol-3'-O-β-D-glucopyranoside Pharmaceutical Raw Materials

目的建立曲札茋苷原料中铅、镉、砷、汞、铜检测方法,测定不同批次中铅、镉、砷、汞、铜残留量。方法采用微波消解样品,以石墨炉原子吸收分光光谱法测铅、镉含量,以火焰原子吸收分光光度法测铜含量,以氢化物发生-原子荧光光谱法测砷、汞含量,并对方法进行方法学考察。结果铅、镉、铜、砷、汞的回收率(n=9)分别为95.18%、96.29%、101.32%、97.88%、86.76%.结论本法简单、快速、准确,可用于原料中铅、镉、铜、砷、汞残留量的测定。

Objective To establish the methods for determination the content of Pb, Cd, Cu, As and Hg in Piceatannol-3＇- O-β-D-glucopyranoside from different batches so as to determine the residue of five elements. Methods Samples were digested with microwave digestion system; the content of Pb and Cd was measured by GFAAS （graphite furnace atomic absorption spectrometry）, the content of As and Hg was measured by HG-AFS （atomic fluorescence spectrometry）, the content of Cu was measured by FAAS （flame atomic absorption spectrometry）, and the measurement methods were methodologically evaluated. Results The recovceries（n= 9） of Pb, Cd, Cu, As, and Hg were 95.18%, 96.29%, 101.32%, 97.88%, 86.76%, respectively. Conclusion These methods are simple and rapid for operating and can be used for the determination of total Pb, Cd, Cu, As and Hg in pharmaceutical raw materials.