金匮温经汤对虚寒证原发性痛经患者微炎症状态的影响

Effect of Jingui Wenjing Decoction to Micro-inflammatory State in Asthenia-cold Syndrome of Primary Dysmenorrhea

目的探讨金匮温经汤对虚寒证原发性痛经患者血清炎症因子的影响,完善金匮温经汤治疗本病的的作用机制。方法收集45例虚寒证原发性痛经患者,给予金匮温经汤连续治疗3个月经周期;45例正常女性作为对照组。比较治疗前后,痛经患者血清炎症相关因子高敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)、高迁移率族蛋白1(HMGB1)的变化。结果痛经组治疗前,血清HsCRP、IL-6、TNF-α、MCP-1和HMGB1均显著升高,与正常组比较,差异具有统计学意义(P<0.05或P<0.01)。治疗后上述指标均有不同程度降低,与治疗前比较,差异具有统计学意义(P<0.05或P<0.01);且治疗后IL-6、MCP-1和HMGB1,与正常组比较,差异具有统计学意义(P<0.05);治疗后Hs-CRP和TNF-α,与正常组比较,差异无统计学意义(P>0.05)。结论虚寒证原发性痛经患者存在微炎症状态,金匮温经汤能够减轻机体的微炎症反应程度,有效治疗虚寒证原发性痛经。

Objective To discuss the effect of Jingui Wenjing decoction to serum inflammatory factors in asthenia-cold syndrome of primary dysmenorrhea, and complete the interventional mechanis of Jingui Wenjing decoction to curing the disease. Methods Collected 45 cases with asthenia-cold syndrome of primary dysmenorrhea, curing with Jingui Wenjing decoction. Collected 45 cases of normal women as control group. Compared the changes of serum inflammatory factors （Hs-CRP, IL-6, TNF-a, MCP-1 and HMGB1） between before and after treatment. Results Dysmenorrhea patients before treatment, the serum Hs-CRP, IL-6, TNF-a, MCP-1 and HMGB1 were significantly increased, compared with normal group, the difference statistically significant （P〈 0.05 or P〈0.01 ）. After treatment, all indices were decreased, compared with before treatment, statistically significant difference （P〈 0.05 or P〈0.01 ）; IL-6,MCP-1 and HMGB1 after treatment compared with normal group, were statistically significant difference（P〈 0.05）; Hs-CRP and TNF-a after treatment compared with normal group, there was no statistically significant difference （P〉0.05）. Conclusion Asthenia-cold syndrome of primary dysmenorrhea have micro-inflammatory state; Jingui Wenjing decoction can effectively treat the asthenia-cold syndrome of primary dysmenorrheal by alleviating micro-inflammatory state.