老年胰腺癌患者外周血循环肿瘤细胞对预后的影响

The clinical significance of circulating tumor cells for prognosis of pancreatic cancer patients

目的:评价老年胰腺癌患者的外周静脉血中循环肿瘤细胞(CTCs)计数对预后的临床应用价值。方法:对20例健康老年人,82例60岁以上胰腺癌患者进行CTCs计数。分析CTCs阳性率与年龄、性别、肿瘤部位、临床分期、细胞分化程度和远处转移的关系。结果:健康老年人外周血中未发现CTCs,胰腺癌患者外周血中CTCs的检出率为60.0%,CTCs阳性率与患者年龄、性别、肿瘤部位无关,与临床分期、细胞分化程度及远处转移明显相关,且远处转移为独立危险因素,有远处转移患者病理阳性的风险是没有远处转移患者的6.447倍。结论:老年胰腺癌患者外周血CTCs计数可以反映患者的疾病状态。其有助于发现隐形微转移、重新确定临床分期及指导患者术后的个体化治疗。CTCs计数对其生存期有较好的预测作用。

Objective To investigate the relationship between circulating tumor cells（CTCs） in peripher- al blood and the prognosis of pancreatic cancer patients. Method From Mar 2010 to Mar 2015, patients with pancreatic cancer in guangzhou first people＇s hospital were enrolled in this study, Immtmomagetic negative en- richhment together with immunofluorescence were used to identify CTCs. The clinical data of all patients were analyzed. Result No CTCs were found in peripheral blood of healthy control cases. The detection date of CTCs was 60.0%. The positive rate of CTCs was closely correlated with cell differentiation and the clinical stage. Conclusion CTCs count in old patients with pancreatic cancer can reflect the status of the patients and is help- ful for the diagnosis of micrometastasis, re-determination of the clinical stage and the guidance of patients＇s treatment. CTCs count can predict the survival time of elderly patients with pancreatic cancer.