帕金森病的抗衰老辅助治疗机制研究

Mechanism of anti-aging therapy on Parkinson's disease

衰老是机体各种生化反应的综合表现,是体内外许多因素(环境污染、精神紧张、遗传等)共同作用的结果。人类社会逐步进入老龄化,老年人在社会中所占的比重越来越大,随着这一现象的发生,各种"老年病"发生的几率也越来越高。已有很多研究表明,抗衰老治疗对一些疾病的预防与辅助治疗具有价值,对帕金森病的治疗,已有临床及实验研究证明了抗衰老治疗的潜在价值,但对于帕金森病抗衰老治疗的作用机制至今没有明确的论述。为此,该文以具有临床报道的中医抗衰老方剂补阳还五汤为载体,探讨帕金森病的抗衰老治疗机制。研究结果发现,在抗衰老的几种机制中,线粒体损伤、细胞凋亡、自由基与氧化应激等机制有助于帕金森病的辅助治疗。该文以补阳还五汤为载体,但所发现的帕金森病的抗衰老辅助治疗机制不仅仅限于补阳还五汤,亦可通过其他抗衰老手段产生类似的结果。该文的贡献主要在于明确了帕金森病抗衰老治疗的机制,为帕金森病的辅助治疗与预防提供了新的策略。

Many studies have shown that anti-aging treatment has value to prevention and treatment of some diseases. For the treat- ment of Parkinson＇ s disease, clinical and experimental researches have proved the potential value of anti-aging treatment, yet the mechanism remains unclear. For this reason, this work used the anti-aging prescriptions of Buyang Huanwu decoction in traditional Chinese medicines example to discover the anti-aging treatment mechanism on Parkinson＇s disease. The results showed that the mecha- nism of mitochondrial damage, apoptosis, free radicals and oxidative stress could contribute to the treatment of Parkinson＇ s disease. Buyang Huanwu decoction is more than as the carrier in this article, the discovered anti-aging treatment mechanism Parkinson＇s disease is not confined to Buyang Huanwu decoction, could also be used to understand the anti-aging treatment mechanism using other prescrip- tion. The main contribution of this paper is to clarify the mechanism of anti-aging treatment of Parkinson＇s disease, and provide a new strategy for the treatment and prevention of Parkinson＇s disease.