2型糖尿病患者脂代谢异常情况及血清载脂蛋白含量分析

Study on the prevalence of lipid metabolism disorders and quantitative analysis of apolipoproteins in T2DM patients

目的了解2型糖尿病患者脂代谢异常情况,分析其血清的各项胆固醇及载脂蛋白含量的差异,以明确各项胆固醇或载脂蛋白与2型糖尿病糖代谢紊乱的相关性。方法分别测定60例经临床确诊的2型糖尿病患者、60例健康对照者血清中空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1、A2、AB48、B100和E的水平,比较2型糖尿病患者以上各指标与健康对照者的差异,并进行相关性、多元逐步回归分析。结果相对于健康对照者,2型糖尿病患者的TC、TG、LDL-C水平显著偏高(P<0.01),HDL-C水平显著偏低(P<0.01),表现为脂代谢异常;血清载脂蛋白A2、B100、E水平均呈现不同程度的显著偏高(P<0.01)。多元逐步回归分析显示Apo B100、Apo B48、LDL-C和TG是空腹血糖水平的主要相关因素,表明载脂蛋白尤其是Apo B与糖代谢紊乱相关。结论 2型糖尿病患者机体内存在脂代谢异常,并且血清载脂蛋白水平与糖代谢紊乱情况密切相关。

Objective To investigate the disorder of lipid metabolism in type 2diabetic patients. To assessed the association of cholesterol and apolipoprotein with derangement of glucose metabolism. Methods The levels of TC,TG,HDL-C,LDL-C,Apo A1,Apo A2,Apo AB48,Apo B100 and Apo E were all measured in 60 type 2 diabetic patients and 60 healthy controls. The differences of these clinical indicators in the two groups have been compared. Correlation analysis,multiple regression analysis have been applied in this paper. Results The levels of TC,TG,LDL-C were significantly higher（ P〈0. 01） and the level of HDL-C was significantly lower（ P〈0. 01） in patients with type 2 diabetes which indicating a lipid metabolic abnormalities. The levels of Apo A2,Apo B100,Apo E were significantly higher in type 2 diabetic patients than those in control group. Multiple regression analysis showed that Apo B100,Apo B48,LDL-C,TG were the main factors of FBG level. It was showed that apolipoproteins,especially Apo B,isassociated with glucose metabolism disorder. Conclusion T2 DM patients are obviously associated with abnormal lipid metabolism,and the apolipoproteins may play an important role in derangement of glucose metabolism.