冠心病患者血清抗丙二醛-乙醛加合物抗体IgG水平变化及其临床意义

Changes and Clinical Significance of Serum IgG Antibodies Against Malondialdehydeacetaldehyde Adducts in Patients with Coronary Heart Disease

目的探讨不同类型冠心病患者血清抗丙二醛-乙醛加合物抗体IgG水平变化及其临床意义。方法87例入选患者根据临床及冠状动脉造影结果分为对照组30例,稳定型心绞痛组15例,不稳定型心绞痛组12例,急性心肌梗死组30例。应用ELISA测定血清抗丙二醛-乙醛加合物抗体IgG水平。结果稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组血清抗丙二醛-乙醛加合物抗体IgG水平显著高于对照组(P<0.05),急性心肌梗死组和不稳定型心绞痛组血清抗丙二醛-乙醛加合物抗体IgG水平显著高于稳定型心绞痛组(P<0.05),而不稳定型心绞痛组和急性心肌梗死组无显著性差异(P>0.05)。结论血清抗丙二醛-乙醛加合物抗体IgG水平和冠心病的发生发展明显相关,对冠心病尤其是急性冠状动脉综合征有很好的预测作用。

Aim To investigate the changes and its clinical significance of serum IgG antibodies against malondialdehyde-acetaldehyde adducts in patients with different types of coronary heart disease. Methods 87 patients were divided into four groups according to the clinical condition and coronary angiography results： control group（ n = 30）,stable angina pectoris group（ n = 15）,unstable angina pectoris group（ n = 12）,acute myocardial infarction group（ n = 30）. Serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts were determined by ELISA. Results The serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts in the stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in the control group（ P 0.05）,the serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts in the acute myocardial infarction group and unstable angina pectoris group were significantly higher than those in the stable angina pectoris group（ P0.05）,there was no significant difference between unstable angina pectoris group and acute myocardial infarction group（ P0.05）.Conclusion The serum levels of IgG antibodies against malondialdehyde-acetaldehyde adducts were related to the development of coronary heart disease,which had a good predictive effect on coronary heart disease,especially in patients with acute coronary syndrome.