红细胞分布宽度预测2型糖尿病患者对比剂肾病

Relationship Between Red Cell Distribution Width and Contrast-induced Nephropathy in Patients of Type 2 Diabetes

目的探讨红细胞分布宽度对行经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的糖尿病患者发生对比剂相关性肾病的预测价值。方法回顾性分析我院2013年1月至2015年12月因急性冠状动脉综合征(acute coronary syndrome,ACS)入院、行PCI治疗的310例糖尿病患者的临床资料,根据手术前后患者的血清肌酐变化分为非对比剂肾病组275例和对比剂肾病组35例。对比剂肾病定义为PCI术后72 h内血肌酐水平较入院基线水平升高25%以上或术后肌酐增幅≥0.5 g/L。结果本次研究发现在同样的危险因素下,术前对比剂肾病组的红细胞分布宽度与非对比剂肾病组相比明显偏高,两者之间差异有统计学意义。Logistic回归分析表明红细胞分布宽度是对比剂肾病的危险因素。结论糖尿病患者在具备同样的危险因素情况下,红细胞分布宽度对行PCI治疗的患者发生对比剂肾病的风险有预测作用。

Aim To explore the predictive value of red cell distribution width（ RDW） for contrast-induced nephropathy（ CIN） in patients of type 2 diabetes with percutaneous coronary intervention（ PCI）. Methods A total of310 ACS patients who received PCI treatment in the hospital from January of 2013 to December of 2015 were retrospectively studied in this project. These patients were divided into 2 groups by serum creatinine before and after surgery： Non-CIN group（ n = 275）; CIN group（ n = 35）,compared to the baseline condition at admission,the patients either had the serum level of creatinine raising up 25% or the serum level of creatinine increasing ≥ 0.5 g / L within 72 hours after PCI. Results The study found that under the same risk factors,compared with Non-CIN group,the RDW in the CIN group had increased,all P0.05. Logistic analysis revealed RDW was the independent risk factor for CIN. Conclusion Elevated RDW has the predictive value for CIN occurrence in type 2 diabetes with PCI treatment.