基质金属蛋白酶9在动脉粥样硬化中的研究进展

The Research Progress of Matrix Metalloproteinase-9 in Atherosclerosis

基质金属蛋白酶9(MMP-9)是一种主要表达于巨噬细胞的含锌离子的蛋白酶,参与了细胞外基质的合成与降解、炎症介质的调控,可促进动脉粥样硬化的发生及进展、血管壁的重构,导致严重的心血管事件发生。本文将重点讨论MMP-9在动脉粥样硬化中的研究进展,并就其在急性心肌梗死的预测价值和心肌梗死后心脏重塑方面加以探讨。

Matrix metalloproteinase-9（ MMP-9）,a proteinase containing Zn2＋mostly expressed in macrophages,has involved in synthesis and degradation of extracellular matrix,as well as regulation of inflammatory mediators,which facilitated the initiation and exacerbation of atherosclerosis and vascular wall remodeling,leading to the occurrence of cardiovascular events. In this review,we focused on the research progress of MMP-9 in atherosclerosis and introduced the predicting value of MMP-9 for acute myocardial infarction and cardiac remodeling of post-myocardial infarction.