支架置入联合动脉灌注治疗中晚期食管癌的临床研究

Clinical study of stent implantation combined with arterial infusion for the treatment of advanced esophageal cancer

目的通过对中晚期中下段食管癌患者进行食管腔内支架置入术联合经导管动脉灌注化疗的比较和分析,探讨中晚期食管癌更加高效、微创的治疗方法,为中晚期食管癌患者的综合介入治疗方案选择提供临床依据。方法以食管腔内支架置入术联合经导管动脉灌注化疗患者29例为支架组;单纯顺铂和5-氟尿嘧啶方案化疗患者30例作为化疗组。对患者生存质量、近期疗效和生存率进行数据统计,采用SPSS13.0软件进行统计学处理和分析。结果支架组生存质量评分、总有效率均高于化疗组,且差异有统计学意义;支架组6个月、12个月生存率高于化疗组,两组间差异虽无统计学意义,但支架组生存率下降的趋势缓于化疗组。结论腔内支架置入术联合经导管动脉灌注治疗中晚期中下段食管癌与单纯化疗相比更为安全、高效、微创,值得临床应用和推广。

Objective Through comparing and analyzing the curative effect of esophageal stent implantation combined with transcatheter arterial infusion chemotherapy for middle-late stage esophageal carcinomas to explore the more efficient and minimally-invasive therapeutic means for middle-late stage esophageal carcinomas in order to provide clinical basis for the selection of comprehensive interventional therapies for patients with middle-late stage esophageal carcinoma. Methods A total of 29 patients with middle-late stage esophageal carcinoma were collected and used as the study group, and esophageal stent implantation combined with transcatheter arterial infusion chemotherapy was employed in all the 29 patients. Other 30 patients with middle-late stage esophageal carcinoma were collected and used as the control group, for them simple chemotherapy regimen of cisplatin plus fluorine urea （ DF regimen） was adopted. The quality of life, short-term curative effect and survival rate of the patients in both groups were statistically analyzed with SPSS13.0 software. Results Both the life quality score and the total effective rate of the study group were higher than those of the control group, the differences between the two groups were statistically significant. Both the 6-month and 12-month survival rates of the study group were higher than those of the control group; although the differences between the two groups were not statistically significant, the decreasing tendency of the survival rate in the study group was slower than that in the control group. Conclusion For middle-late stage esophageal carcinomas, esophageal stent implantation combined with transcatheter arterial infusion chemotherapy is safer, more effective and more mini-invasive than DF regimen, therefore, this technique is worthy of clinical popularization and application.