二维超声联合四维超声诊断产前胎儿畸形的临床分析

Clinical Analysis on Two-Dimensional Ultrasonography Combined with Four-Dimensional Ultrasonography in Diagnosis of Prenatal Fetal Malformations

目的研究二维超声联合四维超声应用于产前胎儿畸形临床诊断中的价值。方法选择2014年11月至2015年12月本院1 600例中晚期孕妇,对其实施产前筛查,针对疑似胎儿畸形孕妇给予二维超声联合四维超声检查和诊断,同时综合分析引产及胎儿降生后的随访资料,对其诊断率进行综合评价。结果 1 600例研究对象中,娩出胎儿数量共计1 611个,属于单胎的有1 589例,其余11例属于双胎。联合诊断法在胎儿畸形诊断符合率上大大高于二维超声诊断法(96.25%vs 85.00%,P<0.05);联合诊断法在胎儿体表畸形诊断符合率上大大高于二维超声诊断法(91.30%vs 73.91%,P<0.05)。结论针对产前胎儿畸形,选择二维超声以及四维超声进行联合检查,能够有效提高临床诊断率,减少出生缺陷,具有较高的临床诊断价值。

Objective To study the value of two-dimensional ultrasonography（2DUS） combined with four-dimensional ultrasonography（4DUS） in diagnosis of prenatal fetal malformations. Methods 1600 cases of pregnant women in second and third trimester admitted to our hospital from N ovember 2014 to December 2015 were selected and given prenatal screening. Pregnant women suspected of fetal malformations were given 2DUS combined with 4DUS for inspection and diagnosis, and the follow-up data of induced labor and fetal birth were analyzed for comprehensively evaluating the diagnostic rate. Results Of 1 600 subjects, the number of newborns were 1 61 1cases, with single birth in 1 589 cases and twin in 1 1 cases. T he diagnostic coincidence rate of fetal malformations of combined method was significantly higher than that of 2DUS（96.25% vs 85.00%, P〈0.05）; the diagnostic coincidence rate of fetal surface malformations of combined method was significantly higher than that of 2D U S（91.30% vs 73.91 %, P〈0.05）. Conclusions 2DUS combined with 4DUS for the diagnosis of prenatal fetal malformations can effectively improve the clinical diagnostic rate, reduce the birth defects, which has higher value for clinical diagnosis.