腺苷蛋氨酸治疗肝内胆汁淤积性乙型病毒性肝炎的临床效果分析

Analysis on the Clinical Effect of Ademetionine in Treating Viral Hepatitis B of Intrahepatic Cholestasis

目的分析腺苷蛋氨酸治疗肝内胆汁淤积性乙型病毒性肝炎的临床治疗效果。方法将100例肝内胆汁淤积性乙型病毒性肝炎患者随机均分为试验组和对照组。对照组给予常规保肝、降酶、退黄、抗病毒治疗,试验组在此基础上给予腺苷蛋氨酸治疗。比较两组的临床疗效、肝功能和凝血指标情况。结果试验组治疗总有效率为90.00%,显著高于对照组的60.00%(P<0.05)。两组治疗后TBIL、ALT、ALP、TA水平均显著改善,且试验组以上指标的改善程度显著优于对照组(P<0.05)。结论肝内胆汁淤积性病毒性肝炎患者在常规治疗方案中加入腺苷蛋氨酸,有助于减轻患者的临床症状,并促进肝功能恢复,值得临床推广。

Objective To analyze the clinical treatment effect of ademetionine in treating viral hepatitis B of intrahepatic cholestasis.Methods 100 cases of patients with viral hepatitis B of intrahepatic cholestasis were randomly and equally divided into experimental group and control group. The control group was given conventional liver protecting, enzyme declining, jaundice removing, antiviral treatment, the experimental group was given ademetionine on the basis of control group. The clinical efficacy, liver function and coagulation indices situations in two groups were compared. Results The total effective rate in experimental group was 90.00%, significantly higher than60.00% in control group（P〈0.05）. The TB IL, A L T, A L P, TA levels in two groups after treatment improved significantly, and the improvement degree of above indices in experimental group was better than that in control group（P〈0.05）. Conclusions A demetionine combined with conventional therapy for patients with viral hepatitis B of intrahepatic cholestasis is conducive to reducing patients＇ clinical symptoms and promoting the recovery of liver function, which is worthy of clinical promotion.