根除幽门螺旋杆菌治疗对预防消化性溃疡复发的临床观察

Clinical Observation of Helicobacter Pylori Eradication in Prevention of the Relapse of Peptic Ulcer

目的探根除幽门螺杆菌(Hp)在消化性溃疡中的治疗效果及对复发的预防效果。方法选取2014年2月至2015年2月我院消化内科收治的150例消化性溃疡合并Hp感染患者为研究对象,根据入院顺序均分为根治组和常规组,常规组给予质子泵抑制剂(奥美拉唑)治疗,根治组给予质子泵抑制剂、阿莫西林、克拉霉素三联治疗。比较两组患者的治疗效果及治疗后3月、6月、12月消化性溃疡复发率。结果根治组患者治疗总有效率高于常规组(97.33%vs 86.67%,P<0.05)。根治组患者治疗后3月、6月、12月消化性溃疡复发率均显著低于对照组(1.33%vs 10.67%,2.67%vs 17.33%,6.67%vs 29.33%,P<0.05)。结论消化性溃疡患者采用根治幽门螺杆菌方法治疗可提高治疗效果,降低复发率。

Objective To investigate the treatment effect of Helicobacter pylori（Hp） eradication in peptic ulcer and the preventive effect on the relapse. Methods 1 50 cases of peptic ulcer patients infected with Hp in our gastroenterology department from February 201 4 to February 201 5 were selected and divided into radical group and conventional group according to the admission sequence. The conventional group was treated with proton pump inhibitors（omeprazole） therapy, the radical group received triple therapy of proton pump inhibitors,amoxicillin, clarithromycin. The treatment effect, recurrence rate of peptic ulcer 3 months, 6 months and 1 2 months after treatment in two groups were compared. Results The total effective rate in radical group was higher than that in conventional group（97.33% vs 86.67%, P〈0.05）. The recurrence rate of peptic ulcer 3 months, 6 months and 1 2 months after treatment in radical group were lower than those in control group（1.33% vs 1 0.67%, 2.67% vs 1 7.33%, 6.67% vs 29.33%, P〈0.05）. Conclusions Hp eradication therapy for patients with peptic ulcer can improve the therapeutic effect, reduce the recurrence rate.