血浆vaspin浓度与急性冠脉综合征的相关性

Study on the correlation between plasma concentration of vaspin and acute coronary syndrome

目的探讨血浆腹腔脂肪型丝氨酸蛋白酶抑制剂(Vaspin)浓度与急性冠脉综合征的相关性。方法选择稳定型心绞痛患者共87例(SAP组),急性冠脉综合征患者共51例(ACS组),另外选择50例冠状动脉正常者为对照组。检测血清vaspin水平,Gensini积分方法评估冠脉病变程度并分析。结果 ACS组血清vaspin水平显著低于SAP组和对照组,ACS组Gensini积分显著高于SAP组和对照组,差异均有显著性(P<0.05)。Spearman相关分析发现,各组血清vaspin水平与Gensini积分具有显著负相关关系(r=-0.762^-0.812;P<0.001)。多支病变组血清vaspin水平显著低于单支病变组和2支病变组。结论血清vaspin水平可作为反映急性冠脉综合征患者冠脉病变的新的血清标记物。

Objective To explore the correlation between plasma concentration of vaspin and acute coronary syndrome. Methods Eighty seven patients with stable angina pectoris（SAP group）and 51 patients with acute coronary syndrome（ACS Group）were enrolled in this study. In addition,50 patients with normal coronary artery were collected as control group. Serum levels of vaspin were detected,and Gensini integral method had been used to assess the coronary lesions,and their results were analyzed. Results Serum level of vaspin in patients of ACS group was significantly lower than that of patients in SAP group. Gensini scores in patients of ACS group were significantly higher than those of patients in SAP group and control group. The result of Spearman correlation analysis showed that serum level of vaspin in patients of each group had significant negative correlation（ r = - 0. 762 ~ - 0. 812;P 〈 0. 001）with Gensini scores. Serum levels of vaspin were significantly lower in patients of multivessel diseased group than those of patients in single - vessel diseased group and two - vessel diseased group. Conclusion Serum level of vaspin can be used as a new serum marker for coronary artery disease in patients with acute coronary syndrome.