摘要
利用胰岛素抵抗HepG2细胞模型筛选具有降血糖活性的鲍姆桑黄孔菌菌丝体化合物,并对其作用机理进行了初步探讨。研究结果表明从鲍姆桑黄孔菌大米发酵菌丝体中分离出的原儿茶醛、柚皮素和黄芩素3种化合物对HepG2细胞葡萄糖消耗量具有明显的促进作用;实时定量PCR分析表明,原儿茶醛对SOCS-3因子mRNA表达抑制效果最好,而黄苓素对TNF-α因子mRNA表达抑制效果最佳。原儿茶醛和黄芩素为鲍姆桑黄孔菌中有降血糖活性的化合物。
The hypoglycemic effects and mechanism of the compounds from Sanghuangporus baumii mycelia are investigated. Three of the compounds, baicalein, naringenine-7-rhamnosidoglucoside and benzaldehyde,3,4-dihydroxy-, effectively promoted the glucose consumption of insulin-resistant HepG2 cells. Benzaldehyde,3,4-dihydroxy had distinct inhibition effects on SOCS-3, and baicalein on TNF-α. Baicalein and benzaldehyde,3,4-dihydroxy- contributed to the reduction of blood sugar.
出处
《菌物学报》
CAS
CSCD
北大核心
2016年第7期857-864,共8页
Mycosystema
基金
国家十二五科技支撑课题(2012BAD36B05)~~
