雷公藤多甙治疗糖尿病肾病的临床疗效

Clinical efficacy of tripterygium glycosides in treating diabetic nephropathy

目的观察雷公藤多甙对糖尿病肾病的治疗效果和安全性。方法糖尿病肾病患者42例随机分为两组:对照组20例,给予糖尿病常规治疗;试验组22例,在常规治疗的基础上加用雷公藤多甙片。测定治疗前后24-h尿蛋白定量、血清白蛋白(Alb)、血清肌酐(SCr)和血尿素氮(BUN)水平。结果治疗前,两组患者24-h尿蛋白、Alb、SCr和BUN比较差异均无统计学意义(P>0.05)。治疗后,治疗组的24-h尿蛋白、SCr和BUN表达均较治疗前降低(P<0.05),而血清Alb升高(P<0.05)。对照组上述指标治疗前后差异均无统计学意义(P>0.05)。两组均无明显不良反应。结论对于糖尿病肾病的患者在给予降糖、降压等综合治疗的基础上,加用雷公藤多甙片可有效改善糖尿病肾病患者的肾脏功能。

Objective To observe the effect and safety of tripterygium glycosides regimen in treating diabetic nephropathy. Methods Forty-two patients with diabetic nephropathy were randomly divided into two groups of A （given conventional treatments） and B （given additional tripterygium glycosides）. The 24-hour urinary protein quantification, serum albumin, serum creatinine（SCr） and blood urea nitrogen（BUN） were measured before and after treatments. Results Before treatment, the 24-hour urinary protein, serum albumin, SCr and BUN were not significantly different between two groups（P〉0.05）. The 24-hour urinary protein, SCr and BUN in group B were significantly decreased and serum albumin was increased after treatment compared to those before （P〈0. 05 ）, which in group A were not significantly different（P〉0. 05）. No significant adverse effects were found in both groups. Conclusion On the basis of basic treatments including lowering blood sugar and blood pressure, additional tripterygium glycosides regimen can effectively improve renal function in the patients with diabetic nephropathy.