摘要
近年来,越来越多的研究表明表观遗传学(epigenetics)与多种疾病密切相关。而胚胎发育的不健全是导致自然流产的重要原因。本文中,我们通过探讨表观遗传学中DNA甲基化和组蛋白修饰与胚胎发育的关系,阐明表观遗传学对反复自然流产(recurrent spontaneous abortion,RSA)的影响,并概述最近几年在动物和人类研究中的进展。
In recent years, a growing number of researches reveal that epigenetics is closely related to many diseases. And the faulty embryogenesis is an important reason of spontaneous abortion. In the present review, we discuss the relationship between recurrent spontaneous abortion （RSA） and embryo development on the basis of DNA methylation and histone modification, present the role of epigenetics in RSA and outline the progress in both animal and human research in recent years.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2016年第7期576-579,共4页
Reproduction and Contraception
