高效抗反转录病毒治疗(HAART)对艾滋病患者血清炎性标志物水平影响研究

Effect of Inflammatory Markers Level on the AIDS Patients' Serum Impacted by Highly Active Antiretroviral Therapy

目的观察艾滋病患者高效抗反转录病毒治疗(HAART)对其血清炎性标志物(TNF-α、Ang-Ⅱ、hs-CRP)水平影响,并与正常人水平比较。方法监测36例HIV/AIDS患者(观察组)接受高效抗反转录病毒治疗(HAART)前和治疗后(6、12个月)的血清高敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、肿瘤坏死因子(tumor necrosis factor,TNF-α)、血管紧张素-Ⅱ(angiotensinⅡ,Ang-Ⅱ)水平,并与36例健康体检者(对照组)相应血清炎性标志物比较。以流式细胞计数法检测CD4+T细胞数、CD4+T/CD8+T值。结果 AIDS接受HAART组治疗前、治疗后6、12个月及正常人静脉hs-CRP、TNF-α、Ang-Ⅱ水平分别为7.37±1.55ml/L,0.75±0.24ng/L,97.2±7.6pg/L、4.65±1.48ml/L,0.48±0.20ng/L,90.0±8.2pg/L、3.82±1.45ml/L,0.40±0.16ng/L,87.2±7.4pg/L和2.68±1.08ml/L,0.32±0.16ng/L,64.2±10.5pg/L。与治疗前比较,治疗6、12个月后的hs-CRP、TNF-α、Ang-Ⅱ水平均有明显降低(P均<0.05);CD4+T细胞数、CD4+T/CD8+T比值升高。结论高效抗反转录病毒治疗可以降低艾滋病患者血清hs-CRP、TNF-α、Ang-Ⅱ等炎性指标水平,提高机体免疫系统功能,控制艾滋病疾病发展。

Objective To observe the effect of highly active antiretroviral therapy （HAART） on the levels of serum inflammatory markers （TNF -α,Ang -Ⅱ ,hs - CRP） in AIDS patients, and compare with the normal levels. Methods Monitoring 36 cases of HIV/ AIDS patients（ observation group） received highly active antiretroviral therapy （HAART） before and after treatment（6 and 12 months） of serum high sensitive C - reactive protein（hs - CRP） ,tumor necrosis factor（TNF -α） and angiotensin Ⅱ （ Ang -Ⅱ） levels, and with 36 healthy volunteers（control group） corresponding serum inflammatory markers compared. Flow cytometry was used to detect the number of CD4＋ T cells and CD4＋ T/CD8 ± T value. Results AIDS patients received HAART treatment group before and after treatment for 6 months,12 months, and normal venous hs - CRP, TNF -α, Ang -Ⅱ levels respectively were 7.37 ± 1.55ml/L,0. 75± 0.24ng/L, 97.2 ±7.6pg/L,4.65× 1.48ml/L,0.48 ± 0.20ng/L,90.0 ± 8.2pg/L,3. 82 ± 1.45ml/L,0.40 ± 0. 16ng/L,87.2 ± 7.4pg/L and 2.68 ± 1.08 ml/L,0.32 ± 0.16ng/L,64.2 ± 10.5pg/L ; and compared with before treatment, treatment for 6 months and 12 months after the hs - CRP,TNF -α, Ang -Ⅱ levels were significantly lower （ P 〈 0.05 ） ; the number of CD4 ± T cells and CD4 ± T/CD8 ± T value in- creased. Conclusion Highly active antiretroviral therapy can reduce the levels of serum hs - CRP,TNF -α, Ang -Ⅱand other inflam- matory markers in AIDS patients, improve the immune system function and control the development of AIDS.