慢性肾病患者的胰岛素抵抗与心血管并发症

The relationship between insulin resistance and cardiovascular disease in chronic kidney disease

胰岛素抵抗是组织器官对胰岛素敏感性下降的一种状态。无论是否合并糖尿病,慢性肾病时均可出现胰岛素抵抗。慢性肾病患者的胰岛素抵抗与其心血管并发症明显相关,改善胰岛素抵抗可减少慢性肾病患者的心血管并发症。文中从慢性肾病的胰岛素抵抗、胰岛素抵抗的可能机制以及胰岛素抵抗导致心血管并发症的机制等方面就慢性肾病患者的胰岛素抵抗与心血管并发症的关系进行综述。

Insulin resistance （IR） is a state of impaired sensitivity to normal circulating level of insulin. Whether complicated with diabetes or not, chronic kidney disease （CKD） has been reported to be associated with IR. Recently, some reports showed that IR was associated with cardiovascular disease （CVD） in CKD and mitigation of IR can reduce GVD in CKD . The relationship of IR and CVD in CKD is reviewed.