外周血内I-FABP联合hs-CRP对溃疡性结肠炎的临床诊断价值

Clinical diagnostic value of I-FABP and hs-CRP for patients with ulcerative colitis

目的分析溃疡性结肠炎(ulcerative colitis,UC)患者血浆肠型脂肪酸结合蛋白(intestinal fatty acid binding protein,I-FABP)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平变化及意义。方法选取宝应县人民医院2012年5月-2015年5月收治的104例UC患者纳入UC组,并选取同期100名健康体检者纳入对照组,比较两组受试者血浆I-FABP、hs-CRP水平差异,并比较不同病变分型、病情活动度患者上述指标差异。结果 UC组血浆I-FABP、hs-CRP水平显著高于对照组,差异有统计学意义(P<0.05)。随着患者病变活动度加重,患者血浆I-FABP、hs-CRP水平逐渐升高,差异有统计学意义(P<0.05)。广泛型组患者血浆I-FABP、hs-CRP水平显著高于左半结肠型组,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,血浆I-FABP与hs-CRP呈显著正相关(r=0.824)。结论随着UC患者病情的进展,血浆I-FABP、hs-CRP水平均显著升高,且二者呈正相关,检测I-FABP、hs-CRP有助于UC临床诊治方案的制定。

Objective To analyze changes and clinical value of intestinal fatty acid binding protein （I-FABP） and hypersensitive C-reactive protein （hs-CRP） for patients with ulcerative colitis （UC）. Methods One hundred and four cases of UC patients were collected, which were treated in the People＇ s Hospital of Baoying Country from May. 2012 to May. 2015. Meanwhile, 100 healthy controls were selected as the control group. The levels of hs-CRP and I-FABP were compared between two groups, the lesion type and disease activity were also compared. Results The levels of I-FABP and hs-CRP in UC group were higher than those in the control group, the difference was statistically significant （P 〈 0.05）. The levels of hs-CRP and I-FABP were increased gradually with the increase of UC activity, and the difference was statistically significant （P 〈 0.05）. The levels of I-FABP and hs-CRP in extensive colitis group were higher than those in the left colon colitis type group, and the difference was statistically significant （P 〈 0.05）. The results of Pear- son correlation analysis showed that the level of I-FABP was positively correlated with hs-CRP （ r = 0. 824）. Conclusion With the progression of UC patients, the plasma levels of hs-CRP and I-FABP are significantly increased, there is a positively correlation between them, the detection of I-FABP and hs-CRP could help to formulate the program of treat- ment and diagnosis for UC.