白藜芦醇治疗腹泻型肠易激综合征的价值

Application value of Resveratrol in the treatment of diarrhea predominate irritable bowel syndrome

目的探讨白藜芦醇治疗腹泻型肠易激综合征(diarrhea predominate irritable bowel syndrome,IBS-D)患者的价值。方法采用随机双盲安慰剂对照的方法,选取2012年2月-2015年6月就诊于菏泽市立医院消化内科门诊的122例IBS-D患者。60例患者纳入白藜芦醇组(300 mg/次,口服,2次/d),62例患者纳入安慰剂组。两组患者均被要求按时服药6周。结果 58例白藜芦醇组患者和59例安慰剂组患者完成了本研究。经过安慰剂治疗,IBS-D患者的睡眠质量得到改善,每日大便次数减少;而在健康相关生活质量(health-related quality of life,QOL)得分、症状自评量表(symptom checklist 90,SCL-90)躯体化得分上,治疗前后差异无统计学意义(P>0.05)。白藜芦醇组IBS-D患者治疗前后在QOL得分、匹兹堡睡眠质量量表(Pittsburgh sleep quality index,PSQI)得分、每日大便次数上差异有统计学意义(P<0.05),而在SCL-90躯体化得分上治疗前后差异无统计学意义(P>0.05)。白藜芦醇在提高患者QOL、改善睡眠质量、减少每日大便次数上强于安慰剂组。结论白藜芦醇在IBS-D治疗方面具有应用价值,有望成为IBS治疗上的一种新型、安全、有效的药物。

Objective To investigate the application value of Resveratrol in the treatment of diarrhea predominate ir- ritable bowel syndrome （IBS-D）. Methods A randomized double blind placebo controlled trial （which including 122 IBS-D patients） was carried out from Feb. 2012 to Jun. 2015 in the Heze Municipal Hospital. Sixty IBS-D patients en- rolled the Resveratrol group （300 mg/time, two times a day） , and 62 IBS-D patients were as the placebo group. Pa- tients in two groups were required to complete the course of treatment, which was 6 weeks. Results Fifty-eight patients in the Resveratrol group and 59 patients in the placebo group completed the course of treatment. After the placebo treat- ment, sleep quality was improved and daily stool frequency was decreased, while, there were no significant differences in the score of health-related quality of life （QOL） and the score of symptom checklist 90 （SCL-90） somatization part （P 〉 0.05）. In the Resveratrol group, there were significant differences in the score of QOL, the total score of Pitts- burgh sleep quality index （PSQI） and daily stool frequency before and after treatment （P 〈 0.05） , however, there was no significant difference in the score of SCL-90 somatization part （ P 〉 0.05 ）. Resveratrol was better than placebo in im- proving the QOL and sleep quality and reducing the daily stool frequency. Conclusion Resveratrol has application val- ue in the treatment of IBS-D, and it may be a new, safe and effective drug in the treatment of IBS.