伊立替康在局部晚期宫颈癌患者新辅助化疗中的应用效果

Clinical Effects of Irinotecan Neoadjuvant Chemotherapy for Cervical Cancer

目的探讨伊立替康在局部晚期宫颈癌患者新辅助化疗中的应用效果。方法按照随机数字表法将114例局部晚期宫颈癌患者均分为实验组和对照组,实验组患者给予伊立替康联合顺铂治疗,对照组患者给予多西他赛联合顺铂治疗,比较2组近期疗效。结果实验组患者RR率明显高于对照组,差异具有统计学意义（P〈0.05）。实验组患者白细胞减少、血小板减少、中性粒细胞减少、恶心呕吐发生率明显低于对照组,差异具有统计学意义（P〈0.05）;实验组患者Ⅲ～Ⅳ级白细胞减少、中性粒细胞减少、恶心呕吐发生率明显低于对照组,差异具有统计学意义（P〈0.05）。2组患者化疗后躯体功能、角色功能、认知功能、情绪功能和社会功能评分均明显升高,与同组化疗前比较,差异具有统计学意义（P〈0.05）;实验组患者化疗后躯体功能和情绪功能均明显高于对照组,差异具有统计学意义（P〈0.05）。结论伊立替康能够有效提高顺铂新辅助化疗的临床效果,减少化疗期间不良反应,提高患者生活质量。

Objective To explore the clinical effects of irinotecan neoadjuvant chemotherapy for cervical cancer. Methods 114 cases of patients with cervical cancer were randomly divided into the experiment group and the control group. The experiment group were treated by irinotecan combined with cisplatin,the control group were treated by docetaxel combine with cisplatin. The clinical effects were compared. Results The rate of RR in the experiment group was higher than that of the control group（ P〈0. 05）; The rate of leukopenia,thrombocytopenia,neutropenia,nausea and vomiting in the experiment group were lower than those of the control group（ P〈0. 05）; The scores of physical functioning,role function,cognitive function,emotional functioning,social function were higher than before chemotherapy（ P〈0. 05）; The physical functioning,emotional functioning in the experiment group were higher than those of the control group（ P〈0. 05）. Conclusion Irinotecan can improve the clinical effects of the patients with cervical cancer,it can reduce toxic reaction,increase quality of life. It can be used as a clinical treatment optimization scheme.