胃癌患者术前行新辅助化疗结合肠内营养支持的临床疗效观察

Clinical Efficacy of Preoperative Neoadjuvant Chemotherapy Combined with Enteral Nutrition Support for Gastric Cancer

目的观察胃癌患者术前行新辅助化疗结合肠内营养支持的临床疗效。方法选取84例进展期胃癌患者为研究对象。随机分为观察组42例和对照组42例。研究组给予术前新辅助化疗结合肠内营养支持治疗,对照组仅给予术前新辅助化疗治疗。观察2组患者营养指标和免疫指标的差异及并发症的发生情况。结果治疗后观察组患者体重、白细胞数、血红蛋白、总蛋白、前清蛋白、转铁蛋白明显高于对照组,差异有统计学意义(P<0.05);观察组患者CD4水平、CD8水平和CD4/CD8明显高于对照组,差异有统计学意义,P<0.05。观察组患者治疗后胃痛、食欲不振、恶心、进食哽咽、腹胀、黑便化疗相关并发症发生率均明显低于对照组,差异有统计学意义(P<0.05)。结论胃癌患者术前行新辅助化疗结合肠内营养支持可以明显改善患者化疗后的营养状况和免疫水平,增强患者对手术的耐受力,有利于提高患者的生活质量。

Objective To observe the clinical effects of neoadjuvant chemotherapy combined with enteral nutrition support for gastric cancer. Methods 84 cases of advanced gastric cancer were randomly divided into the study group（ 42 cases） and the control group（ 42 cases）. The study group was given preoperative neoadjuvant chemotherapy combined with enteral nutrition therapy,the control group received preoperative neoadjuvant chemotherapy treatment. The differences in nutritional,immune parameters and the occurrence of complications between the 2 groups were observed. Results After treatment,weight,white blood cell count,hemoglobin,total protein,prealbumin and transferrin of the observation group were significantly higher those of the control group,the difference was statistically significant（ P〈0. 05）. The levels of CD4,CD8 and CD4 / CD8 in the observation group were significantly higher than those of the control group,the difference was statistically significant,P〈0. 05. Chemotherapy related complications such as stomach pain,loss of appetite,nausea,eating choked,abdominal distension,and melena of the observation group were significantly lower than those of the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Neoadjuvant chemotherapy combined with enteral nutrition support can significantly improve the nutritional status and immune level of patients with gastric cancer after chemotherapy. It can enhance the patient＇s tolerance to the operation and improve the quality of life of patients.