维生素E稳定型交联超高分子量聚乙烯在骨关节置换中的研究进展

Vitamin E-stabilized ultrahigh molecular weight polyethylene in joint replacement

背景:维生素E稳定型交联超高分子量聚乙烯作为最新一代的聚乙烯分子材料,近年来已被广泛应用于各类人工关节置换中,然而其磨损及因磨损产生的溶骨反应仍是影响疗效的重要因素。目的:旨在探讨和总结维生素E稳定型交联超高分子量聚乙烯的生物特性及应用进展,为指导维生素E稳定型交联超高分子量聚乙烯在临床中的开展寻求理论基础。方法:第一作者计算机检索中国知网和MEDLINE数据库。检索词为"ultra-high molecular weight polyethylene;vitamin E-stabilized;joint replacement;application"。检索语言设置为英文。结果与结论:共检索到92篇文章,根据纳入和排除标准,对文献进行筛选,最终纳入46篇。结果表明,维生素E稳定型交联超高分子量聚乙烯不仅能够进一步加强假体材料的各项理化特性,同时能够与自由基结合,提高假体材料的抗氧化率,延长假体材料的远期疗效。但仍然缺少大量临床案例及随访调查作为依据,远期临床疗效仍有待评估。

BACKGROUND： As the latest generation of ultrahigh molecular weight polyethylene, vitamin E-stabilized ultrahigh molecular weight polyethylene has been widely put into use of various kinds of joint replacement. However, wear debris and osteolysis caused by that are still the vital factor influencing the clinical curative effect. OBJECTIVE： To discuss and summarize the material characteristics and application progress of vitamin E-stabilized ultrahigh molecular weight polyethylene, and to seek the theoretical basis which can guide us to launch vitamin E-stabilized ultrahigh molecular weight polyethylene clinically. METHODS： The first author retrieved the CNKI and Medline databases by computer. The keywords were ＂ultra-high molecular weight polyethylene, vitamin E-stabilized, joint replacement, application＂ in English. RESULTS AND CONCLUSION： Totally 92 articles were retrieved. According to the inclusion and exclusion criteria, 46 articles were included in result analysis. The results show that vitamin E-stabilized ultrahigh molecular weight polyethylene can not only enhance the physicochemical property of prosthesis but also can integrate with free radicals to increase antioxidant rate of prothesis in order to prolong the long-term curative effect of prosthesis. However, it is still lack of vast of clinical cases and follow-up as evidence. In case of that, long-term clinical efficacy remains to be assessed.