腹腔镜与开腹手术治疗卵巢良性肿瘤对免疫功能的影响

The impact of laparoscopic and open surgery on immune function in patients with benign ovarian tumor

目的比较腹腔镜与开腹手术治疗卵巢良性肿瘤对患者免疫功能的影响。方法将100例疗卵巢良性肿瘤患者采用随机列表法将分为观察组和对照组,每组50例。观察组采用腹腔镜行卵巢良性肿瘤剥除术,对照组采用经腹部卵巢行良性肿瘤剥除术。记录两组患者术后的免疫功能检查情况和并发症情况。结果观察组T淋巴细胞亚群（CD4/CD8）、免疫球蛋白（Ig G）明显优于对照组（P〈0.05）,两组比较,差异有统计学意义;观察组并发症发生率为12.0%（6/50）,对照组的并发症发生率为38.0%（19/50）;观察组明显少于对照组,两组比较,差异有统计学意义（P〈0.05）。术后门诊随访观察组和对照组子宫内膜异位症发生率分别为4.0%和16.0%;随访6~12个月,观察组下腹隐痛2例,复发1例;对照组下腹隐痛7例,复发1例。结论对卵巢良性肿瘤患者行腹腔镜下卵巢良性肿瘤剥除术,可有效减少患者机体免疫功能损伤,降低术后并发症的发生率。

Objective To explore the impact of laparoscopic and open surgery on immune function in patients with benign ovarian tumor. Methods A totol of 100 cases with ovarian benign tumors were randomly divided into observation group and control group,50 cases in each group. Patients in observation group received laparoscopic ovarian benign tumor resection,and patients in control group received laparotomy ovarian benign tumor resection. The postoperative immune function and complications were compared between the two groups. Results The T lymphocyte subsets（ CD4 / CD8）,immunoglobulin（ Ig G） of observation group were betterthan those of control group（ P〈0. 05）,the differences were statistically significant（ P〈0. 05）; The incidence rate of complications in observation group was 12%（ 6 /50）,control group was38%（ 19 /50）,the difference was statistically significant（ P〈0. 05）. Follow-up for 6-12 months,endometriosis incidence rate in observation group was 4. 0% and control group was 16. 0%; abdominal pain2 cases,recurrence 1 case in observation group; abdominal pain 7 cases,recurrence 1 case in control group.Conclusion Compared with open surgery,laparoscopic ovarian benign tumor resection can effectively reduce the immune function of patients,and reduce the incidence of postoperative complications.