系统性红斑狼疮精神损害临床研究进展

Psychiatric Systemic Lupus Erythematosus: An Overview and Update

系统性红斑狼疮精神损害,即精神狼疮,包括急性狂乱状态、焦虑症、认知功能障碍、情感障碍和精神病等。本综述着重分析精神狼疮的临床表现、发病机制、诊断和治疗,随着神经免疫学、神经影像学及临床治疗学的进展,早期诊断、积极评估及目标治疗可以明显控制疾病发作、改善患者生活质量及提高其预期寿命。未来的研究方向应更关注于患者的临床注册、疾病活动性评价及难治性病例干预的研究。

At present,psychiatric systemic lupus erythematosus（ PSLE）,which includes acute confusional state,anxiety disorder,cognitive dysfunction,mood disorder and psychosis,is common in neuropsychiatric lupus.This article discusses the status of research on PSLE in the past few years,which include characteristics of clinical presentations,etiopathological mechanisms,neuroimaging diagnosis and therapeutic strategy. Along with the advance in technology of neuroimmunology and neuroimaging,early diagnosis,effective assessment and treat-to-target strategy could effectively decrease global disease activity,improve quality of life and increase life expectancy. Furthermore, prospective researches should focus on PSLE registries,neuropsychiatric questionnaires, damage index and intervention of severe refractory cases in clinical practice.