治疗性血管新生的潜在靶点——高密度脂蛋白

High-density lipoprotein., a potential target for therapeutic angiogenesis

研究表明高密度脂蛋白（high density lipoprotein，HDL）是心血管疾病的独立危险因素，与缺血性心脏病及动脉粥样硬化相关缺血性疾病发病率呈负相关。对于缺血性心脏病患者，治疗性血管新生已经显现出良好的增加心肌灌注的作用。现重点概述HDL对血管内皮损伤的修复作用和对血管新生的促进作用，旨在为缺血性心脏病的治疗性血管新生提供新思路。

Prior studies have shown that high-density lipoprotein （HDL） is an independent risk factor for cardiovascular disease and is inversely correlated with the incidence of ischemic heart disease as well as other atherosclerosis-related ischemic conditions. Therapeutic angiogenesis has proved to be promising in increasing myocardial perfusion for patients with ischemic heart disease. This review focuses on the effects of HDL on repairing endothelial injury and promoting angiogenesis, aiming to provide new insights on therapeutic angiogenesis for ischemic heart disease.