脓毒症心肌抑制发病机制研究现状

Research status on pathogenesis of myocardial depression in sepsis

心血管系统在脓毒症中起关键作用，普遍认为脓毒症心肌抑制与脓毒症的发病率和病死率增加有关。目前对脓毒症心肌抑制没有一个共识的定义，但可以认为是心肌（收缩性和舒张性）功能障碍，包括左心和右心。脓毒症心肌抑制的发病机制牵涉多种因素，包括遗传、分子、代谢、结构等。现对脓毒症心肌抑制的发病机制研究现状进行综述。

The cardiovascular system plays a key role in sepsis,and septic myocardial depression is a common finding associated with increased morbidity and mortality. Myocardial depression during sepsis is not clearly defined,but it can perhaps be best described as a global （ systolic and diastolic） dysfunction of both the left and right sides of the heart. The pathogenesis of septic myocardial depression involves a complex mix factor of genetic, molecular, metabolic, and structural. Now, the research status on pathogenesis of myocardial depress in sepsis was reviewed.