丝素基伤口敷料研究进展

Research progress of wound dressing based on silk fibroin

目前丝素基伤口敷料的研究主要集中于应用静电纺技术制备含功能性物质的理想伤口敷料。添加纳米金属和抗生素等功能成分虽可增强敷料的抗菌性,却引发了细胞毒性与抗药性,威胁生物体安全。基于此,从创造微湿伤口环境、增强抗菌性能、支持细胞生长和刺激伤口愈合4个方面,综述了近年来国内外通过新型技术、复合多组分材料和功能成分制备丝素基伤口敷料的研究进展;展望了以多组分天然材料为基材,利用新技术制备添加天然抗菌药物敷料的广阔前景,以期为丝素基伤口敷料的临床应用研究提供有益参考。

At present,the research on silk fibroin wound dressing mainly focused on the preparation of ideal wound dressing containing functional material by electrostatic spinning technique.Although functional component including nano metal and antibiotics can enhance the antimicrobial properties of the dressing,the addition of such components triggers cellular toxicity and drug resistance,which was harmful to organisms.Therefore,from the creation of moist wound environment,enhancement of antibacterial activity,supporting cell growth and stimulating wound healing,this paper reviews the research progress of wound dressings based on silk fibroin including new technologies,combination of multicomponents,and functional materials at home and abroad in recent years.In addition,the broad prospects of wound dressing prepared by the addition of natural antibacterial into multicomponent natural materials are indicated.The research is expected to provide beneficial references for clinical application of wound dressings.