冠心病合并糖尿病患者血清胱抑素C水平之间相关性

目的评估冠心病（CAD）合并糖尿病（DM）患者血清胱抑素c（CysC）水平的变化。方法入选51例经冠状动脉造影检查确诊的cAD患者，病例分为两组：单纯cAD组27例，cAD＋DM组24例；测定患者的血清Cysc浓度，采用Gensini积分法定量评估冠状动脉病变程度。比较两组患者血清Cysc水平的差异；分析血清Cysc浓度与冠状动脉病变程度的相关性。结果cAD＋DM组患者血清Cysc水平和Gensini积分高于单纯cAD组（P〈0．05）；Pearson相关分析显示，血清Cysc水平与Gensini积分值呈正相关（r=0．33，P〈0．05）。结论血清Cysc检测有助于反映冠状动脉病变严重程度。CADff并DM患者血清Cysc水平较高。

Objective To assess the serum cystatin C （ Cys C ） levels in coronary artery disease （ CAD ） patients with diabetes mellitus （ DM ） . Methods A total of 51 angiographically diagnosed CAD patients were included in this study. Patients were divideded into two groups： CAD without DM （ n=27 ） and CAD with DM （ n=24 ） . Serum Cys C concentrations were measured. The severity of CAD was calculated using Gensini scoring. Serum Cys C levels in CAD wih DM were compared with those in CAD without DM. The relationship of serum Cys C with the severity of CAD was examined. Results Serum Cys C levels and Gensini score in CAD patients with DM were significiantly higher than those without DM （ P〈0.05 ） . Pearson correlation analysis revealed that the Cys C levels were positively correlated with the CAD Gensini score （ r=0.33, P〈0.05 ） . Conclusion Serum Cys C concentration reflects the severity of CAD. Compared with CAD without DM, CAD with DM have higher levels ofCys C.