复方红豆杉合剂辅助替吉奥治疗IV期老年胃癌临床疗效及安全性探讨

目的探讨复方红豆杉合剂辅助替吉奥治疗Iv期老年胃癌患者临床疗效及安全性。方法 选取2011年10月至2014年10月收治Iv期老年胃癌患者共130例，以随机区组法分为对照组（65例）和观察组（65例），分别采用替吉奥单用和在此基础上加用复方红豆杉合剂辅助治疗；比较两组患者临床治疗总有效率、临床获益率、平均无进展生存时间、治疗前后KPS评分、免疫功能指标及毒副作用发生率等。结果观察组患者临床总有效率和获益率均显著高于对照组，差异有统计学意义（19〈0．05）；观察组患者平均无进展生存时间显著长于对照组，差异有统计学意义（P〈0．05）；观察组患者治疗后KPS评分显著高于对照组，差异有统计学意义（P〈0．05）；观察组患者治疗后免疫功能指标显著优于对照组，差异有统计学意义（P〈0．05）；观察组患者药物毒副作用发生率显著低于对照组，差异有统计学意义（P〈0．05）。结论复方红豆杉合剂辅助替吉奥治疗Iv期老年胃癌患者可有效控制病情进展，延长生存时间，提高生存质量及免疫系统功能，且有助于降低药物毒副作用发生风险。

Objective To investigate the clinical effects and safety of compound Hongdoushan prescription combined with S-1 in the treatment of eldely patients with gastric cancer in IV stage. Methods 130 patients with eldely patients with gastric cancer in IV stage were chosen in the period from October 2011 to October 2014 at our hospital and randomly divided into both group including control group （ 65 patients ） with S-1 used alone and observation group （ 65 patients ） with compound Hongdoushan prescription on the basis of control group; and the clinical total effective rate, clinical benefit rate, the average progression free survival time, KPS score and immune function indicators before and after treatment and toxic side effects of drug of both groups were compared. Results The clinical total effective rate and clinical benefit rate of observation group was significantly better than control group （ P〈0.05 ） . The average progression free survival time of observation group was significantly longer than control group （ P〈0.05 ） . The KPS scores after treatment of observation group was significantly better than control group and before treatment （ P〈0.05 ） . The levels of immune function indicators after treatment of observation group was significantly better than control group and before treatment （ P〈0.05 ） . The toxic side effects of drug of observation group was significantly lower than control group （ P〈0.05 ） . Conclusion Compound Hongdoushan prescription combined with S-1 in the treatment of eldely patients with gastric cancer in IV stage can efficiently control the disease progress, prolong the survival time, higher the quality of life and immune system function and be helpful to reduce the risk of toxic side effects of drug.