1日龄五指山猪胸腺的解剖及组织形态学观察

An atomy and histology observation of the thymus in one-day-old Wuzhishan pigs

五指山猪是我国特有的微型猪种,是人类医学实验动物理想模型。本研究为进一步提供五指山猪胸腺免疫功能的形态学资料,以1日龄五指山猪为试验动物,采用常规的解剖学和组织学技术,观察了1日龄五指山猪胸腺的解剖学及组织学特点。结果表明:1日龄五指山猪胸腺特别发达,呈Y字型,由胸叶、中叶和颈叶3个部分构成,其中,颈叶特别发达,向前延伸达颌下腺背侧;胸腺指数0.856 9%,平均长度9.64cm;光镜下,1日龄五指山猪由表面的被膜和深层的实质构成,被摸和小叶间结缔组织不发达,实质分为外周的皮质和内部的髓质,皮髓分界清晰,实质主要由淋巴细胞、上皮细胞和嗜酸性粒细胞等构成,髓质内胸腺小体主要是小型胸腺小体和少量的幼稚胸腺小体,未观察到衰老的胸腺小体。

Wuzhishan pig is a mini pig which is unique to China,and it is also an ideal animal model for human medical experiments.In order to further provide the morphological data of thymus immune function in Wuzhishan pig,Wuzhishan pig was taken as a experimental animal,and the anatomical and histological features of one-day-old Wuzhishan pig＇s thymus were observed by the conventional anatomy and histology technology.The result shows that the Wuzhishan pig＇s thymus are Y-shaped and well-developed,which includes three parts：the chest lobe,the middle lobe,and the neck lobe.The neck lobe is most developed that extending forward of the back side of the submandibular gland.Thymus index is 0.856 9%,and the average length is 9.64 cm.It is consist of the exterior films and the interior essences under light microscope.The connective tissue of films and interlobulars is not well-developed.The interior essences are devided into the outer cortex and internal medulla.The medulla has a clear boundary and the cortex is mainly composed of large number of cortical lymphocytes and a small amount of epithelial cells and eosinophils cells.However,the thymic corpuscle in medulla is mainly made by a large number of small size thymus corpuscle and a small amount of navie thymic corpuscle,there is no aging thymus corpuscle.