IL 12B基因多态性与Graves病相关性的Meta分析

Meta-analysis of the association between IL 12B gene polymorphism and Graves' disease

目的 Meta分析评价IL 12B基因3＇UTR 1188A/C多态性与Graves病的相关性。方法设定入选条件,检索Pub Med、EMbase、中国知网、重庆维普、万方数据库,收集关于IL12B基因3＇UTR 1188A/C多态性与Graves病相关性的文献,对符合入选条件的研究进行异质性检验Meta分析,计算不同遗传模型下1188A/C多态性与Graves病发病的相关性。结果 5篇文献纳入研究,包括747名病例和698名对照。合并分析结果显示,IL12B基因3＇UTR 1188A/C多态性与Graves病发病风险性无统计学意义（显性遗传模型：OR=1.18,95%CI=0.24～2.17,P=0.59;隐性遗传模型：OR=1.61,95%CI=0.97～2.67,P=0.06;等位基因模型：OR=1.32,95%CI=0.93～1.87,P=0.12）。对3个日本人群的研究进行亚组分析,结果亦未发现1188A/C多态位点的变异与GD发病有统计学相关性（显性遗传模型：OR=0.78,95%CI=0.45～1.37,P=0.39;隐性遗传模型：OR=1.15,95%CI=0.87～1.52,P=0.31;等位基因模型：OR=0.99,95%CI=0.83～1.18,P=0.92）。结论 IL12B基因1188A/C多态性可能与GD发病相关性无关,但由于研究样本数较少,尚需大样本研究加以证实。

Objective To assess the association between 1188 A/C polymorphism of IL12 B 3＇UTR and Graves＇ disease（GD） by meta-analysis.Methods The relevant studies about the correlation between IL12 B 3＇ UTR1188 A/C polymorphism and GD were collected by searching Pub Med,EMbase,CNKI,VIP and CBM according to the inclusion criteria.Heterogeneity tests and meta-analysis were conducted.Results Five studies consisting of747 cases and 698 controls were included.The results of meta-analysis showed that there was no significant difference between the 1188 A/C polrmorphism of IL12 B 3＇UTR and GD（for dominant genetic model：OR = 1.18,95%CI = 0.24 ～ 2.17,P = 0.59;for recessive genetic mode：OR = 1.61,95% CI = 0.97 ～ 2.67,P = 0.06;for allelic genetic model：OR = 1.32,95% CI = 0.93 ～ 1.87,P = 0.12）.In the 3 Japanese studies of the correlation between 1188 A/C polymorphism and the susceptibility of GD,no statistically signicant correlation was found（for dominant genetic model：OR = 0.78,95% CI = 0.45 ～ 1.37,P = 0.39;for recessive genetic mode：OR = 1.15,95% CI = 0.87 ～ 1.52,P = 0.31;for allelic genetic model：OR = 0.99,95% CI = 0.83 ～ 1.18,P = 0.92）.Conclusion There is no significant correlation between IL 12 B 3＇UTR 1188 A/C polymorphism and GD.