生物可降解镁合金覆膜支架治疗兔颈内动脉动脉瘤的可行性分析

Research of the Feasibility of Biodegradable Covered Magnesium Alloys Stent for a Rabbit Model of Lateral Aneurysm in the Carotid Artery

目的研究具有生物降解特性的镁合金覆膜支架对于兔颈内动脉动脉瘤治疗的可行性。方法利用40只新西兰大白兔建立颈内动脉动脉瘤模型,分别使用Willis覆膜支架和镁合金覆膜支架植入对实验兔进行治疗。定期对植入支架的实验兔进行血管造影检查和钼靶检查,观察植入支架后动脉瘤的情况、颈内动脉的情况和支架的降解程度。结果所有大白兔造模成功,20只大白兔植入了Willis覆膜支架,20只大白兔植入了镁合金覆膜支架。血管造影检查结果显示,植入支架后40只大白兔的动脉瘤均显示为腔闭塞状态,且动脉瘤所处的颈内动脉通畅;3个月后植入镁合金覆膜支架的20只大白兔的动脉瘤均显示为腔闭塞状态且颈内动脉通畅,而植入Willis覆膜支架的19只正常,1只大白兔颈内动脉呈现出闭塞状态;植入1年后19只大白兔动脉瘤治愈,1只大白兔的颈内动脉闭塞未完全痊愈。钼靶检查结果显示镁合金覆膜支架具有生物降解的特性,随着时间的延长而降解,而Willis覆膜支架并不随着时间延长而降解。结论具有生物降解特性的镁合金覆膜支架治疗兔颈内动脉动脉瘤较传统治疗方式具有更好的疗效。

Objective To discuss the feasibility of biodegradable covered magnesium alloys stent for a rabbit model of lateral aneurysm in the carotid artery. Methods The carotid artery lateral aneurysm model was deemed successful in 40 rabbits. The biodegradable covered magnesium alloys stents or Willis covered stents were inserted after model making. Angiography was performed prior to the procedure,3,6 and 12 months after stent implantation to evaluate the disappearance of the aneurysms and patency of the carotid artery. The degradation behaviour was invastagated with molybdenum target after stent placement. Results The carotid artery lateral aneurysm model was deemed successful in 40 rabbits,and biodegradable covered magnesium alloys stents and Willis covered stents were implanted in 20 and 20 aneurysms,respectively. DSA after biodegradable covered magnesium alloys stent placement displayed disappearance of the aneurysms and patency of the in all 20 rabbits during follow-ups. DSA 3 months after Willis stent placement displayed patency of the carotid artery in 19 rabbits and occlusion of the artery in one. No occlusion of the carotid artery was observed on angiography at 12 months. The degradation of the biodegradable covered magnesium alloys stent was investigated with molybdenum target during followups,and no changes was observed in Willis covered stent. Conclusion Biodegradable covered magnesium alloys stent is a feasible approach for the treatment of a lateral aneurysm in the carotid artery.