枸橼酸莫沙必利与埃索美拉唑联合治疗胃食管反流病临床疗效及安全性分析

Clinical Efficacy and Safety of Mosapride Combined With Esomeprazole in the Treatment of Gastroesophageal Reflux Disease

目的探讨枸橼酸莫沙必利与埃索美拉唑联合治疗胃食管反流病疗效及安全性。方法选取2012年1月~2015年1月在我院诊疗的76例胃食管反流病患者作为研究对象,分为两组,研究组和对照组各38例,研究组用枸橼酸莫沙必利与埃索美拉唑联合治疗,对照组单独应用埃索美拉唑治疗,比较两组患者治疗前后的症状评分、总有效率、不良反应发生情况。结果治疗后研究组和对照组的症状评分均较治疗前有较明显降低,治疗后研究组的症状评分低于对照组,差异有统计学意义（P〈0.05）。研究组的总有效率与对照组比较更高,差异有统计学意义（P〈0.05）。研究组的不良反应发生率与对照组比较,差异无统计学意义（P〉0.05）。结论枸橼酸莫沙必利与埃索美拉唑联合使用治疗胃食管反流病可发挥协同作用,患者的临床症状显著缓解,临床治疗效果提高,安全性较高。

Objective To investigate the clinical efficacy and safety of mosapride and esomeprazole in the treatment of gastroesophageal reflux disease.Methods From January 2012 to 2015,76 cases of patients with gastroesophageal reflux disease were selected in our hospital and were divided into study group and control group,38 patients in each group,study group treated with mosapride and esomeprazole,control group treated with esomeprazole,to compare the symptom score before and after treatment,total efficiency,adverse events of two groups.Results After treatment,the symptom scores of study group and control group were significantly lower than before treatment,the symptom scores of the study group after treatment was lower than the control group,the difference was statistically significant（P〈0.05）.The total effective rate of study group was higher than that of control group,the difference was statistically significant（P〈0.05）.There were no statistically significant differences about adverse reaction incidence between study group and control group（P〈0.05）.Conclusion Mosapride combined with esomeprazole in the treatment of gastroesophageal reflux disease can play a synergistic effect,the clinical symptoms of patients are significantly relieved,the effect of clinical treatment is improved,and the safety is high.