补肾益智方联合丁苯酞对阿尔茨海默病患者Aβ,GSH-Px,SOD及MDA水平的影响

Effect of Bushen Yizhi Decoction Combined with Butylphthalide on GSH-Px,Aβ,SOD and MDA Levels in Patients with Alzheimer's Disease

目的:探讨补肾益智方联合丁苯酞对阿尔茨海默病患者谷胱甘肽过氧化物酶(GSH-Px),β淀粉样蛋白(Aβ),超氧化物岐化酶(SOD)及丙二醛(MDA)水平的影响。方法:74例阿尔茨海默病患者按照随机数字表法分为对照组和治疗组,各37例。对照组患者给予口服丁苯酞软胶囊,治疗组患者在对照组治疗的基础上加服补肾益智方进行治疗,12周为1个疗程。治疗后,对比分析两组阿尔茨海默病患者简易智能精神状态检查量表(MMSE)评分、日常生活活动能力量表(ADL)评分,GSH-Px,Aβ,SOD及MDA水平的变化情况。结果:治疗后两组患者MMSE和ADL评分较治疗前均得到明显改善(P<0.05),治疗组患者改善的程度优于对照组(P<0.05)。治疗后两组患者Aβ的水平较治疗前明显降低(P<0.05),治疗组患者降低程度大于对照组(P<0.05)。治疗后两组患者SOD和GSH-Px水平较治疗前明显升高(P<0.05),治疗组升高程度大于对照组(P<0.05)。治疗后治疗组患者MDA水平明显降低(P<0.05),治疗组明显低于对照组(P<0.05)。结论:补肾益智方联合丁苯酞可通过改善患者认知功能障碍和机体抗氧化应激的功能,从而明显提高患者生活自理能力和认知记忆能力,值得临床进一步推广使用。

Objective： To investigate the effect of Bushen Yizhi decoction combined with butylphthalide on glutathione peroxidase （ GSH-Px ） , amyloid β-protein （ Aft ）, superoxide dismutase （ SOD ） and malondia!dehyde （MDA） levels in patients with Alzheimer＇s disease. Method： The 74 patients with Alzheimer＇s disease were randomly divided into treatment group （37 cases） and control group （37 cases） according to the random number table method. Patients in control group were treated with oral butylphthalide soft capsule, and patients in treatment group also received Bushen Yizhi decoction based on the treatment in control group, with 12 weeks as a course of treatment. After treatment, minimum mental state examination （MMSE） scale scores, activity of daily living （ADL） scale scores, Aft, SOD, GSH-Px and MDA levels were compared and analyzed between two groups of patients with Alzheimer＇s disease. Result： After treatment, the MMSE and ADL scores of both groups were significantly improved （P 〈 0.05 ）, the degree of improvement in treatment group was more obvious （P 〈 0.05 ）. After treatment, the levels of Aβ in both groups were significantly decreased （P 〈 0.05）, the extent of the reduction in the treatment group was more obvious （P 〈 0.05 ） , SOD and GSH-Px levels in both groups were significantly increased after treatment （P 〈 0.05） , and the extent of increase in the treatment group was more obvious （P 〈 0.05）. The level of MDA in the treatment group was significantly decreased after treatment, and it was lower than that of the control group after treatment （P 〈 0.05）. Conclusion： Bushen Yizhi decoction combined with butylphthalide can improve the cognition impairment and the function of the body＇s resistance to oxidative stress, thus significantly improving the self-care ability and their ability of learning and memory for the patients, so it is worthy of further promotion.