血浆sLOX-1水平与冠状动脉慢血流的相关性

Correlation between plasma sLOX-1 levels and coronary slow flow phenomenon

目的探讨血浆可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与冠状动脉慢血流的相关性。方法该研究共纳入82名冠脉慢血流患者(慢血流组,n=82)及184名冠脉血流正常者(对照组,n=184),采用酶联免疫吸附(ELISA)法测定两组的血浆sLOX-1水平并比较,采用参照心肌梗死溶栓治疗后(thrombolysis in myocardial infarction,TIMI)血流帧数(TFC)评价冠脉血流速度。通过多元Logistic回归分析评价血浆sLOX-1水平与合并冠心病的独立相关性,采用Spearman相关分析评价血浆sLOX-1水平与平均TMI-TFC的相关性。结果慢血流组患者血清sLOX-1水平显著高于对照组[0.94(0.48-1.30)vs 0.47(0.39-0.86)ng/ml,P<0.001]。多元Logistic回归分析显示血浆s LOX-1水平是预测冠脉慢血流独立危险因子(优势比2.044,95%可信区间1.274-3.279;P=0.003)。Spearman相关分析结果显示,血浆sLOX-1水平与TIMI-TFC呈显著正相关(rs=0.315,P=0.004)。结论血浆sLOX-1水平与冠脉慢血流的发生及严重程度存在独立正相关,sLOX-1有望成为预测冠脉慢血流风险并对其进行危险分层的重要生物标记物。

Objective To explore the correlation between plasma sLOX-1 levels and coronary slow flow phenomenon（ CSFP）. Methods Eighty-two patients with CSFP and 184 controls with normal coronary flow were enrolled. Plasma sLOX-1 levels were determined by enzyme-linked immunosorbent assay（ ELISA） and compared between the two groups. Coronary flow rate was assessed by thrombolysis in myocardial infarction（ TIMI） frame count（ TFC）. Multivariate Logistic regression was used to analyze the independent association between plasma sLOX-1 levels and CSFP. Spearman correlation coefficient was performed to assess the correlation between plasma sLOX-1 levels and mean-TFC. Results Plasma s LOX-1 levels in CSFP group were significantly higher than those in control group[0.94（ 0.48-1.30） ng/ml vs 0.47（ 0.39-0.86） ng/ml,P〈0.001]. Multivariate Logistic regression analysis demonstrated that sLOX-1 was the independent predictor of CSFP（ odds ratio 2.044,95% CI 1.274-3.279; P= 0.003）. Spearman correlation analysis revealed that plasma sLOX-1 level was positively correlated with mean-TFC（r=0.311,P=0.004）. Conclusion The plasma sLOX-1 levels is independently associated with the presence and severity of CSFP,suggesting that sLOX-1 might be a potential biomarker for CSFP prediction and risk stratification.