苯磺酸氨氯地平和莫索尼定对老年高血压患者血压变异性和血清脂联素水平的影响

Clinical Study on the Effect of Amlodipine Besylate and Moxonidine on Blood Pressure Variability and Serum Adiponectin Concentrations in Elderly Patitents with Hypertension

目的比较苯磺酸氨氯地平和莫索尼定对老年高血压病患者24h动态血压变异性和血清脂联素水平的影响。方法选取120例老年高血压患者,随机分为A、B两组,A组(n=56)口服苯磺酸氨氯地平片,5mg/d;B组(n=58)口服莫索尼定,0.2mg/d。监测两组患者服药前及服药4周后24h动态血压,计算体质量指数(BMI),并检测血清脂联素水平。结果两种降压药物均能有效降低血压及血压变异性;治疗后,A组24hSBP、24hDBP、24hSBPV和24hDBPV均低于B组,两组24hSBPV和24hDBPV比较,差异有统计学意义(P<0.05),A组BMI水平高于B组(P<0.05),而血清脂联素水平低于B组(P<0.05)。结论在降低血压变异性上,苯磺酸氨氯地平优于莫索尼定;在控制BMI及血清脂联素水平上,莫索尼定优于苯磺酸氨氯地平。

Objective To investigate the effects of amlodipine besylate and moxonidine on blood pressure variability and serum adiponectin concentrations in elderly patients with hypertension .Methods 120 patients with hypertension were divided into two groups of A and B .Patients in Group A （n=56） took amlodipine besylate orally at doses of 5 mg/d ,while patients in Group B（n=58）took moxonidine tablets orally at doses of 0.2 mg/d .24‐hour ambulatory blood pressure （ABP） ,body mass index （BMI）and serum adiponectin concentrations were monitored before the treatment and 4 weeks after the treatment respectively .Results The blood pressure and BPV in both groups were lower after treatment than before treatment .24‐hour systolic blood pressure （SBP） ,24‐hour diastolic blood pressure （DBP） ,24‐hour systolic blood pressure variability （SBPV ） ,and 24‐hour diastolic blood pressure variability （DBPV） were significantly lower in Group A than in Group B （P〈 0.05） ,while BMI and serum adiponectin concentrations is significantly higher in Group A than in Group B （P〈0.05） .Conclusion Amlodipine besylate is superior to moxonidine in improving the 24‐hour blood pressure variability ,while moxonidine is better than amlodipine besylate in improving BM I and serum adiponectin concentrations .