造血生长因子对再生障碍性贫血合并肺部感染患者免疫指标的影响研究

Effect of hematopoietic growth factor for T lymphocyte subsets,procalcitonin and high sensitivity C reactive protein in patients with aplastic anemia complicated with pulmonary infections

目的分析造血生长因子对再生障碍性贫血患者合并肺部感染的疗效以及对T淋巴细胞亚群、降钙素原和超敏C反应蛋白的影响,为再生障碍性贫血合并肺部感染寻找新的治疗方法。方法选择2013年2月-2015年6月收诊的再生障碍性贫血并发肺部感染的患者80例,随机分为对照组和观察组各40例,对照组接受常规免疫抑制和抗感染治疗,观察组则在此基础上加造血生长因子治疗;统计并分析两组间疗效,比较组间差异。结果治疗后再生障碍性贫血治疗总有效率观察组为95.00%,显著高于对照组,组间差异有统计学意义(P<0.05);观察组肺部感染治疗的总有效率为97.75%,观察组显著高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CD_4^+、CD_4^+/CD_8^+为(27.19±5.34)%、(0.98±0.13),显著高于对照组;观察组CD_8^+、PCT、hs-CRP分别为(41.23±6.17)%、(8.02±3.41)g/L、(74.10±18.45)mg/L,显著低于对照组,组间差异有统计学意义(P<0.05)。结论造血生长因子能有效逆转机体免疫失衡,有利于再生障碍性贫血合并肺部感染患者病情的改善,对患者的预后有很大的帮助。

OBJECTIVE To study the effect of hematopoietic growth factor for T lymphocyte subsets,procalcitonin and high sensitivity C reactive protein in patients with aplastic anemia complicated with pulmonary infections,so as to find new therapeutic method for the treatment of aplastic anemia with pulmonary infections.METHODS Totally80 cases of patients with aplastic anemia complicated with pulmonary infections from Jun.2015 to Feb.2013 in our hospital were randomly divided into two groups,the control group and the observation group,each group had40 cases.Patients in the control group took conventional immunosuppressive therapy and anti infective therapy,and those in the observation group were treated with combined hematopoietic growth factor.Then the differences of efficacy between two groups were compared,and T cell subsets and serum levels of C reactive protein levels in two groups of patients before and after treatment were detected and compared too.RESULTS Regeneration barrier anemia treatment the total effective rate of observation group was 95.00%,observation group,the total effective rate was significantly higher than that of the control group,the difference between the two groups has significance（P〈0.05）after treatment;observation group with pulmonary infection treatment of total effective rate was 97.75%,the observation group was significantly higher than that of the control group（P〈0.05）.After treatment,observation group,CD4^＋,CD4^＋/CD8^＋（27.19＋5.34）%,（0.98＋0.13）was significantly higher than that of the control group.The observation group CD8^＋,hs-CRP,PCT were（41.23＋6.17）%,（8.02＋3.41）g/L,（74.10＋18.45）mg/L which was significantly lower than that in control group and between group（P〈0.05）.CONCLUSION Hematopoieticgrowth factor can effectively reverse the immune imbalance in the body,it will be conducive to the improvement of the condition of patients with aplastic anemia complicated with pulmonary infection and a great help to the prognosis of patients.