小剂量尿激酶治疗老年短暂性脑缺血发作的临床研究

The Clinical Study About the Elderly Patients with Transient Ischemic Attack Using Small Dose of Urokinase Therapy

目的探究小剂量尿激酶治疗老年短暂性脑缺血发作(TIA)的临床疗效。方法选取我院2015年1月至2016年1月收治的60例TIA患者作为研究对象,随机分为治疗组(30例)和对照组(30例),对照组采用常规疗法,治疗组在对照组的基础上加用小剂量尿激酶。结果治疗组的有效率显著高于对照组;治疗组能显著降低纤维蛋白原(Fib)和D-二聚体(DD)以及颈动脉粥样硬化斑块平均面积差异具有统计学意义(P<0.05)。结论小剂量尿激酶对老年性TIA的治疗效果显著,值得在临床上推广与使用。

Objective To investigate the clinical efficacy of the elderly patients with transient ischemic attack（TIA） using small dose of urokinase therapy. Methods 60 TIA patients were included during January 2015 to January 2016 in our hospital, and they were randomly divided into treatment group and control group, each group had 30 patients. The patients in the control group were treated with traditional method, and the patients in the treatment group were added small dose of urokinase therapy. Results The efficacy rate was significantly higher in the treatment group than in the control group, and the levels of Fibrinogen（Fib） and D-Dimer（DD） and the average area of carotid atherosclerotic plaque were decreased after therapy in then treatment group, with significant difference（P〈0.05）. Conclusion Small dose of urokinase is an effective treatment to old TIA patients, and this method is worth to generalize.