镇静治疗对颅脑外伤高颅压患者预后的影响

Effect of Sedation Treatment on the Prognosis of Patients with Intracranial Hypertension after Craniocerebral Trauma

目的探讨镇静治疗对颅脑外伤高颅压患者预后的影响。方法研究对象选取我院近年来收治颅脑外伤高颅压患者共80例,采用随机数字表法分为对照组和治疗组,每组40例。对照组患者采用大骨瓣减压术治疗,治疗组患者则在术前给予右美托咪定治疗;比较两组患者术后不同时间点Ramsay镇静评分,颅内压水平及格拉斯哥预后(GCS)评分。结果治疗组患者术后不同时间点Ramsay评分和颅内压水平均显著低于对照组,差异有统计学意义(P<0.05);治疗组患者术后12个月GCS评分显著高于对照组,差异有统计学意义(P<0.05)。结论镇静治疗用于颅脑外伤高颅压患者可有效提高镇静程度,降低颅内压水平,并有助于改善远期预后。

Objective To investigate the effects of sedation treatment on the prognosis of patients with intracranial hypertension after craniocerebral trauma. Methods 80 patients with intracranial hypertension after craniocerebral trauma were chosen in recent year in our hospital and randomly divided into 2 groups including control group（40 patients） with large bone flap decompression operation used alone and observation group（40 patients） with dexmedetomidine treatment on the basis of control group; and the Ramsay sedation score, intracranial pressure level and glasgow coma scale（GCS） at different time points after operation of both groups were compared. Results The Ramsay sedation score and intracranial pressure level at different time points after operation of observation group was significant better than control group（P〈0.05）. The GCS scores in 12 months after operation of observation group was significant better than control group（P〈0.05）. Conclusion Sedation treatment on the prognosis of patients with intracranial hypertension after craniocerebral trauma can efficiently higher sedation degree, decrease the levels of intracranial pressure and be helpful to improve the long-term prognosis.