PCT、CRP、WBC检测对儿童细菌感染的诊断价值

The Diagnostic Value of Serum Procalcitonin,C-reactive Protein and White Blood Count for Bacterial Infection in Childhood

目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)3种检测指标对儿童细菌感染的诊断价值,为临床及时确诊提供有价值检测指标。方法将住院患儿分为细菌感染组(A组)、病毒感染组(B组)、同时设健康对照组(C组);静脉采血测定PCT、CRP、WBC,比较3种指标水平,分析这些指标的诊断敏感性及特异性。结果 A组PCT、CRP、WBC明显高于B组、C组(P<0.05);B组PCT、WBC与C组比较无统计学意义(P>0.05),CRP高于C组有统计学意义(P<0.05);PCT、CRP、WBC诊断细菌感染的敏感性分别为98.5%、98.8%、81.2%;特异性分别为82.8%、42.4%、68.0%。结论 PCT、CRP、WBC三项检测指标,各有优缺点,联合检测,能及早进行诊断及鉴别诊断,以指导合理使用抗菌药物,避免抗菌药物滥用,延缓细菌耐药产生。

Objective To investigate the serum procalcitonin（PCT） and C reactive protein（CRP）, white blood cell count（WBC） 3 testing indicators in diagnosis of bacterial infections in Childhood, provide valuable index for clinical diagnosis of detection. Methods The inpatients were divided into bacterial infection group（group A） and viral infection group（B group）, and health control group（group C）; determination of venous blood PCT, CRP, WBC, the comparison of 3 kinds of indexlevel, analysis of sensitivity and specificity of these indexes. Results A group of PCT, CRP, WBC were higher than that in B group, C group（P〈0.05）; comparison of PCT and WBC with B group and C group, no statistical significance（P〉0.05）, B group CRP was higher than that in group C, with statistical significance（P〈0.05）; PCT, CRP, WBC for the diagnosis of bacterial infection susceptibility respectively98.5%, 98.8%, 81.2%; specificity were respectively 82.8%, 42.4%, 68%. Conclusion Three indexes of PCT, CRP and WBC, each has advantages and disadvantages, joint detection, early diagnosis and differential diagnosis, so as to guide the rational use of antimicrobial drugs, avoid antibacterial drug abuse, retard bacterial drug resistance.